THE QUEST TO QUELL QUACKERY (Alternate title for article break THE PATENT MEDICINE MENACE) by Pam North Medicine shows had their origins long before the United States became a nation, beginning in fourteenth-century Europe. American medicine shows employed traveling entertainers who could draw audiences to which the "doctors" could direct elaborate sales pitches hawking their cure-alls. The major firms of the era, such as the Kickapoo Indian Medicine Company (headquartered in Connecticut, nowhere near any 19th-century center of Indian population) used the medicine show as a vehicle for their promotions, and also published a variety of advertising materials to promote their products independently of the show. These publications often allied their nostrums with the herbal knowledge of the American Indian, exotica, religion, patriotism, mythology or new developments in science - anything to sell the products. Nostrums permeated American society by the late 19th century, and there were no constraints to prevent the extravagant claims made as to theirproducts' curative powers, nor to keep their contents from including questionable and dangerous ingredients, as in the morphine and alcohol-laced syrups for teething and colicky babies. Patent medicine makers extolled the nearly-magical virtues of their products to cure any and all known diseases, such as cancer, arthritis and tuberculosis. They advertised baldness remedies, bust developers, manhood restorers, and answers to feminine physical complaints. They held no monopoly on the market; the ethical pharmaceutical industry, which advertised directly to the health professionals, sold their share of patent medicines as well. Patent medicines' long and shady history in America reaching its zenith in the late 19th century, when the population became more urban and somewhat more capitalized, a ripe target for charlatans best characterized by the dictum, "caveat emptor." Communications had expanded; the printed word became a crucial venue for the proliferation of patent medicines; the rise of advertising in America, not coincidentally, paralleled the rise of nostrums. At the same time, the biomedical sciences in this country were still in their infancy, with medicine ill-equipped to deal with most diseases. Countless enterprising and unscrupulous individuals were prepared to step in and make claims to alleviate physical suffering. The success of patent medicines was attrbiutable to several factors. Access to medical practioners was very limited, especially in rural areas, and 19th century medical technology was primitive by today's standards. These products, appealing in their highly-touted abilities to cure, offered ease and convenience of purchase (from the traveling show or the local general store), and were a preferred alternative to some of the unpleasant medical procedures (such as bloodletting) of the era. Many of the patent medicines contained alcohol (some were almost entirely alcohol) and narcotics (morphine, cocaine and opium), and these ingredients usually had the effect of making the patient feel better for a while, even if they fell short of the claims of being wonder cures. Quacks developed successful marketing techniques, but they also promoted their interests by using their econmic strength to subdue any curiosity in the press. By the 1890s, patent medicine manufacturers used so-called "red clauses" (contracts of silence) in their advertising contracts with newspapers and magazines. These muzzle clauses voided the contract if a state law regulating nostrums was passed. Many editorials thus were not only silent on the need for such laws, but actively campaigned against them. An estimated annual figure paid out to newspapers by the proprietary medicine companies exceeded twenty million dollars - averaging more than one thousand dollars to each newspaper in the United States. Charlatans and their trade associations were not able to successfully stifle the entire issue, however. A few muckraking journalists helped expose the red clauses, false testimonials and claims, and products' harmful ingredients. A series written by Samuel Hopkins Adams in Collier's in 1905, entitled "The Great American Fraud," followed by another series on doctors who advertised fake clinics, revealed many startling and disturbing facts to the American public. The publication of another work by socialist Upton Sinclair, entitled The Jungle, a fact-based novel about immigrant life in the meat-packing industry of Chicago, primed the final push for federal law. The first federal Food and Drugs Act was passed four months later. The wriitngs of Adams and Sinclair had a major impact on passage of the bill, as did the untiring work of other organizations. The law prohibited adulteration and misbranding of food and drugs, and though it had many shortcomings, it was definitive and beneficial. The federal legislations of the early 20th century, both in the U.S. and Canada, in which manufacturers were required to list the ingredients in their products, and were prohibited from making false promises and claims about benefits and results, almost brought about the demise of the entire industry. Some products continued to be sold well into the 1950s and beyond,however, but in altered form. The legislation, while not eliminating quackery completely, brought disclosure and accountability into the marketplace, an important first step in consumer protection. Illustrations for article are at: http://www.nlm.nih.gov/exhibition/ephemera/medshow.html